Pre-analytical and analytical confounders of serum calprotectin as a biomarker in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Correlation between Serum Levels of Calprotectin with Disease Activity in Rheumatoid Arthritis Patients
Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease defined by chronic synovitis and progressive joint destruction. This study investigated calprotectin as a serological marker in the hope of establishing an adequate means of diagnosing RA and following up on patients. Materials and Methods: This cross-sectional study included 32 RA patients who were referred to the rh...
متن کاملPre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis.
Variability in pre-analytical blood sampling and handling can significantly impact results obtained in quantitative immunoassays. Understanding the impact of these variables is critical for accurate quantification and validation of biomarker measurements. Particularly, in the design and execution of large clinical trials, even small differences in sample processing and handling can have dramati...
متن کاملChasing the Effects of Pre-Analytical Confounders – A Multicenter Study on CSF-AD Biomarkers
INTRODUCTION Core cerebrospinal fluid (CSF) biomarkers - Aβ42, Tau, and phosphorylated Tau (pTau) - have been recently incorporated in the revised criteria for Alzheimer's disease (AD). However, their widespread clinical application lacks standardization. Pre-analytical sample handling and storage play an important role in the reliable measurement of these biomarkers across laboratories. AIM ...
متن کاملSerum big endothelin-1 as a biomarker in oral squamous cell carcinoma patients: an analytical study
UNLABELLED Detection of abnormally elevated levels of molecules in patients with oral cancer may be useful in early diagnosis. These markers can be included in current Histopathology grading and in TNM staging systems of Oral Squamous Cell Carcinoma (OSCC) to make it more efficient. Several pro-angiogenic molecules have been assessed for the same reason. Endothelin-1 (ET-1) is a vasoactive pept...
متن کاملPre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders
BACKGROUND Vascular endothelial growth factor-A (VEGF-A) is intensively investigated in various medical fields. However, comparing VEGF-A measurements is difficult because sample acquisition and pre-analytic procedures differ between studies. We therefore investigated which variables act as confounders of VEGF-A measurements. METHODS Following a standardized protocol, blood was taken at three...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine (CCLM)
سال: 2019
ISSN: 1437-4331,1434-6621
DOI: 10.1515/cclm-2019-0508